Ongoing and past major R&D programs of Syngulon:
Research Program BREAKthrough
BREAKthrough is funded under Horizon Europe’s Marie Skłodowska-Curie Actions (MSCA) programme
Research partners: UCLouvain (coordinator) + 8 beneficiaries and 7 associated partners (including Syngulon)
Period: 2023 – 2026
Objective: Breaking the barrier – An integrated multidisciplinary approach to kill Gram-negative bacteria through existing antibiotics by making their outer membrane permeable
Research Program CRITIC
BEWARE 2022 (H2020-MSCA-COFUND)
Research partner: UCLouvain
Period: 2022 – 2024 
Objective: demonstrating the potential interest of specific bacteriocins as a new therapeutic option against intracellular infections by S. aureus, in preclinical models
Research Program SKINCURE
Research partner: UCLouvain
Period: 2022 – 2026
Objective: PhD Thesis about post-modified bacteriocins against skin pathogenic bacteria
Research Program PROSECO
Research partner: Micalis INRAE
Period: 2021 – 2023
Objective: PROteases and SErpins to COntrol half-life of bacteriocins
Research Program ELITHE
Research partners: UNamur, ULiège, FytoFend
Period: 2021 – 2025
Objective: The ELITHE consortium is proposing a breakthrough innovation through the development of the first biobased elicitor for wheat cultivation.
Research Program BaCLEM
Research partners: ULiège, Süleyman Demirel University, IPGP, EXITCOM
Period: 2020 – 2023
Objective: Bio-assisted Closed loop recycling of E-Mobility. Metals from waste PCBs and Li-Ion Batteries
Research Program STOPPERSIST
Research partner: ULB
Period: 2020 – 2024
Objective: PhD Thesis about bacteriocins against persistant bacteria (UPEC)
Research Program RPR 2
Research partner: UCLouvain
Period: 2020 – 2022
Objective: Development of bacteriocins against drug resistant Mycobacterium tuberculosis and Vibrio Cholerae
Research Program PhD thesis (2)
PhD Doctoral Training Programs: 1 BBSRC (Biotechnology and Biological Sciences Research Council) + 1 MRC iCASE (Medical Research Council industrial Collaborative Awards in Science and Engineering)
Research partner: Imperial College
Period: 2019 – 2022
Objective: Development of bacteriocins potential for human pathogen control including AntiMicrobial Resistance (AMR) and persistance
Research Program STAPHCONTROL
Research partner: ULB
Period: 2019 – 2023
Objective: PhD Thesis about bacteriocins against drug resistant Staphylylococcus aureus
Research Program EVOL-MODEL
Research partner: UCL
Period: 2018 – 2021
Objective: Development of an evolutionary system to increase the number and properties of bacteriocins and modelisation of microbial consortia.
One of Syngulon’s scientists is hosted as an invited scientist in the laboratories of Dr. Chris Barnes and Dr. Vitor Pinheiro at University College London. This strategic collaboration with these top scientists will allow Syngulon to develop a unique knowledge of directed evolution of bacteriocins and modelisation of microbial consortia relevant to the industry.
Research Program ERA CoBioTech – ComRaDes
Research partners: ULiège, TU Delft, Universität Stuttgart
Industrial partner: DSM, Centrient Pharmaceuticals
Period: 2018- 2021
Objective : Developing scale-up/scale-down approach to improve industrial fermentation.
This international program includes top academic scientists, Prof. Frank Delvigne (University of Liège), Prof. Robert F. Mudde (TU Delft), Prof. Ralf Takors (Universität Stuttgart).
Syngulon’s role for the ComRades project is to apply synthetic biology to streamline strains based on the needs of the partners.
Research Program OligoCar
Research partners: ULiège, VITO
Industrial partners: Lambers-Seghers, Fytofend
Period: 2018 – 2019
Objective : Explore the production of oligo-carrageenans in the industry (phyto applications and feed applications).
Production of recombinant carrageenases to generate oligo-carrageenan for industrial needs.
Syngulon’s role is to provide genetic systems of recombinant carrageenases compatible with standard industrial practices.
Research Program RPR
Research partner: UCLouvain
Period: 2017 – 2019
Objective: Development of bacteriocin-based genetic technologies applied to Gram-positive bacteria.
One of Syngulon’s scientists (Dr. Johann Mignolet) is hosted in the lab of Prof. Pascal Hols. This strategic collaboration allows Syngulon to have access to unique knowledge on the genetics of Gram positive bacteria, more specifically, their bacteriocins.
Research Program ALGOTECH
Research partners: UMons, ULB, UCLouvain
Period: 2017 – 2020
Objective: Algotech is an academic network built for optimisation of bioproduction with an emphasis on microalgae.
As one of the industrial partners, Syngulon has a strategic focus on the synthetic biology aspects of the network.
Research Program PARAGEN
Research partner: Tereos
Period: 2017 – 2019
Objective: Development of a unique library of bacteriocin genetic elements through synthetic biology. This library is organized by industrial application, and are made available to our partners to improve their microbial-based processes (i.e. avoiding microbial contamination).
To make this library pertinent for industry, Syngulon has built strategic partnerships with leading companies in the bioeconomy.
Research Program E.S.T.
Research partner: Gembloux AgroBiotech – Pr. Frank Delvigne
Period : 2016 – 2019
Objective : scale up of fermentation technologies for the production of recombinant products in E. coli.
Our bacteriocin technologies are aimed at improving industrial biofermentation production through increased product yield, contamination prevention. We work with Prof. Frank Delvigne from the University of Liège (Gembloux AgroBiotech) to scale up from the bench to industrial-scale fermenters.
Syngulon’s Research Programs are supported by:
You must be logged in to post a comment.